Selective inhibition with sodium cyanate of protein synthesis in colon cancer cells.

@article{Allfrey1977SelectiveIW,
  title={Selective inhibition with sodium cyanate of protein synthesis in colon cancer cells.},
  author={Vincent G. Allfrey and Lidia C. Boffa and G. Vidali},
  journal={Cancer},
  year={1977},
  volume={40 5 Suppl},
  pages={2692-8}
}
Sodium cyanate, which in its tautomeric acidic form, isocyanic acid, acts as a protein carbamylating reagent, has been previously shown to inhibit selectively both DNA and protein synthesis in a variety of solid tumors. We have now compared its effects on protein synthesis in normal colonic epithelium and in colon tumors induced by the administration of 1,2-dimethylhydrazine to rats. The incorporation of 3H-amino acids into cytoplasmic and nuclear protein fractions was suppressed to a much… CONTINUE READING