Selective inhibition of warfarin metabolism by diltiazem in humans.

@article{Abernethy1991SelectiveIO,
  title={Selective inhibition of warfarin metabolism by diltiazem in humans.},
  author={Darrell R. Abernethy and L. Kaminsky and Q. Todd Dickinson},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={257 1},
  pages={
          411-5
        }
}
Healthy men were administered i.v. racemic warfarin, S-warfarin or R-warfarin on two occasions, once in the drug-free state and once during concomitant administration of oral diltiazem 120 mg three times daily. Blood samples for determination of plasma warfarin and diltiazem concentrations, the prothrombin time and complete urine collections were obtained for determination of urinary excretion of dehydrowarfarin, 4'-hydroxywarfarin, 6-hydroxywarfarin, 7-hydroxywarfarin, 8-hydroxywarfarin and… CONTINUE READING

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