Selective inhibition of vitamin D hydroxylases in human keratinocytes.

  title={Selective inhibition of vitamin D hydroxylases in human keratinocytes.},
  author={Inge Schuster and Helmut Egger and Daniel D Bikle and Gerda Herzig and Gudimetla Satyanarayana Reddy and Anton Stuetz and P. St{\"u}tz and Georg Vorisek},
  volume={66 3-5},
Human keratinocytes convert 25(OH)D(3) to hormonally active 1alpha,25(OH)(2)D(3) and respond to its antiproliferative/prodifferentiating action in vitro and in vivo. Levels and activity of 1alpha,25(OH)(2)D(3) are short-lived. 1alpha,25(OH)(2)D(3) induces 24-hydroxylase (CYP24) that rapidly metabolizes the hormone, yielding a cascade of side-chain oxidized products and this eventually results in the loss of activity. Aiming at stabilizing the levels of active hormone, we have searched for… CONTINUE READING

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