Selective inhibition of synaptosomal proline uptake by leucine and methionine enkephalins.

@article{Rhoads1983SelectiveIO,
  title={Selective inhibition of synaptosomal proline uptake by leucine and methionine enkephalins.},
  author={D E Rhoads and Neil A Peterson and E. Raghupathy},
  journal={The Journal of biological chemistry},
  year={1983},
  volume={258 20},
  pages={12233-7}
}
The high affinity, sodium-dependent uptake of proline by rat brain synaptosomes was inhibited by the opioid pentapeptides, Leu-enkephalin and Met-enkephalin. The synaptosomal uptake of other putative neurotransmitter amino acids including glutamic acid, aspartic acid, gamma-aminobutyric acid, and taurine was not altered in the presence of enkephalins. The uptake of a neuroinactive amino acid, leucine, was also unaffected by enkephalins. The extent of proline uptake was half-maximal at a Leu… CONTINUE READING