Selective inhibition of rat hepatic microsomal cytochrome P-450. I. Effect of the in vivo administration of cimetidine.

@article{Chang1992SelectiveIO,
  title={Selective inhibition of rat hepatic microsomal cytochrome P-450. I. Effect of the in vivo administration of cimetidine.},
  author={Thomas K. H. Chang and Marc S. Levine and Stelvio M Bandiera and Gail D Bellward},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1992},
  volume={260 3},
  pages={1441-9}
}
Cimetidine is considered to be a general inhibitor of cytochrome P-450 enzymes, but there is indirect evidence that certain cytochrome P-450 enzymes are not inhibited by cimetidine. The purpose of this study was to determine whether cimetidine, when administered in vivo to adult male Wistar rats, selectively inhibits hepatic microsomal cytochrome P-450… CONTINUE READING