Selective inhibition of monoamine oxidase in monoaminergic neurons in the rat brain

@article{Ask2004SelectiveIO,
  title={Selective inhibition of monoamine oxidase in monoaminergic neurons in the rat brain},
  author={Anna Lena Ask and Ingrid Fagervall and Svante B. Ross},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={324},
  pages={79-87}
}
SummaryThe prevention by six reversible and selective monoamine oxidase-A (MAO-A) inhibitors (α-ethyltryptamine, harmaline, 4-methoxyamphetamine, amiflamine [FLA 336(+)], N-desmethylamiflamine [FLA 788(+)] and N,N-desmethylamiflamine [FLA 668(+)] of the phenelzineinduced irreversible MAO inhibition in the rat brain was examined. By using crude synaptosome preparations of hypothalamus and striatum incubated with low substrate concentrations of 14C-serotonin (1×10−7 M), 14C-noradrenaline (2.5×10… Expand
Selective inhibition by amiflamine of monoamine oxidase type A in rat brain, liver and duodenum
  • A. Ask
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
TLDR
The results in this study suggest that other factors than a low interaction with intestinal MAO may be of importance for the low tyramine potentiating effect obtained after oral administration of amiflamine. Expand
Selective inhibition by 4,α-dimethyl-m-tyramine (H77/77) and 4-methyl-α-ethyl-m-tyramine (H75/12) of the monoamine oxidase within serotonergic and noradrenergic neurons in the rat brain
Summary1. The inhibition of monoamine oxidase (MAO) by 4,α-dimethyl-m-tyramine (H77/77) and 4-methyl-α-ethyl-m-tyramine (H75/12), two amine releasing compounds, within monoaminergic neurons in theExpand
Release of 3H-5-hydroxytryptamine by amiflamine and related phenylalkylamines from rat occipital cortex slices
TLDR
It is concluded that compounds which were effective releasers of 5-HT in vitro were those that are transported into the serotonergic neurons by the 3H-5-hydroxytryptamine carrier in vivo and has in addition an ability to mobilise vesicular 5- HT. Expand
Relation between brain monoamine oxidase (MAO) activity and the firing rate of locus coeruleus neurons
TLDR
Electrophysiological and biochemical results show that the neuronal depression of noradrenaline neurones in the LC byMAO-inhibitors is specifically related to the inhibition of MAO-A, which indicates a relationship between the activity of intrasynaptosomally located MAo-A and the neuronal activity of central nor adrenaline pathways. Expand
Stereoselective inhibition of monoamine oxidase and semicarbazide-sensitive amine oxidase by 4-dimethylamino-2,α-dimethylphenethylamine (FLA 336)
TLDR
Ex vivo experiments indicated that there was no significant irreversible inhibition of rat heart and lung SSAO after both single and repeated administration of amiflamine at doses up to 20 times higher than required for inhibition of MAO-A within central serotoninergic neurones. Expand
Inhibition of 5-hydroxytryptamine accumulation and deamination by substituted phenylalkylamines in hypothalamic synaptosomes from normal and reserpine-pretreated rats
  • A. Ask, S. Ross
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
TLDR
A classification of uptake inhibitors, releasing compounds, and MAO inhibitors that are and that are not transported by the 5-HT carrier may be performed by measuring the inhibition of the uptake and the deamination in synaptosomes from normal and reserpine-pretreated rats. Expand
Effects of a monoamine oxidase A inhibitor, FLA 668 (+) on the adrenergic mechanisms of the dog saphenous vein
TLDR
It is concluded that FLA 668(+) is, in the saphenous vein of the dog, a selective inhibitor of MAO type A and that it exerts a cocaine-like effect. Expand
Monoamine oxidase and head-twitch response in mice. Mechanisms of alpha-methylated substrate derivatives.
TLDR
The response induced by HTR-inducers is significantly enhanced by combined treatment with a non-selective form of monoamine oxidase (MAO) inhibitor, and the relationship between MAO activity and HTR caused by these drugs (especially, alpha-methylated analogous compounds which 5-fluoro-alpha-methyltryptamine and p-hydroxyamphetamine) is presented in detail. Expand
Comparative effects of dehydropirlindole and other compounds on rat brain monoamine oxidase type A
  • J. Gérardy, A. Dresse
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2002
TLDR
DHP behaves as a reversible MAO-A inhibitor whose potency is situated between that of befloxatone and harmaline, and the aim of this work was to compare the inhibitory potency of DHP with three reference compounds. Expand
The inhibition of the cage-leaving response—A model for studies of the serotonergic neurotransmission in the rat
TLDR
It was observed that rats that had been given drugs that enhance serotonergic neurotransmission did not leave their home-cages when the grid-covers were removed in contrast to normal rats who almost immediately left the cages. Expand
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