Selective inhibition of monoamine oxidase A and B by two substrate-analogues, 5-fluoro-alpha-methyltryptamine and p-chloro-beta-methylphenethylamine.

@article{Kinemuchi1986SelectiveIO,
  title={Selective inhibition of monoamine oxidase A and B by two substrate-analogues, 5-fluoro-alpha-methyltryptamine and p-chloro-beta-methylphenethylamine.},
  author={Hiroyasu Kinemuchi and Yasuhiro Arai},
  journal={Research communications in chemical pathology and pharmacology},
  year={1986},
  volume={54 1},
  pages={125-8}
}
In order to develop new and potent reversible MAO-B-selective inhibitors, we examined the inhibitory effects of two substrate-analogues, 5-fluoro-alpha-methyltryptamine (5-FMT) and p-chloro-beta-methylphenethylamine (p-CMP) on rat brain MAO-A and -B activity in vitro. Studies of the inhibitory effects of both analogues showed that 5-FMT was a highly MAO-A-selective inhibitor, whereas p-CMP was a highly MAO-B-selective inhibitor. The degree of inhibition by 5-FMT or p-CMP was not enhanced by… CONTINUE READING