Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics

@article{Sato1999SelectiveIO,
  title={Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics},
  author={T. Sato and Shigeo Kitayama and Chieko Mitsuhata and T Ikeda and Katsuya Morita and Toshihiro Dohi},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1999},
  volume={361},
  pages={214-220}
}
  • T. Sato, S. Kitayama, T. Dohi
  • Published 17 January 2000
  • Biology, Chemistry
  • Naunyn-Schmiedeberg's Archives of Pharmacology
Abstract. Synthetic local anesthetics (LAs) have been found to have cocaine-like characteristics with some psychotomimetic action, possibly through monoaminergic neurotransmission. To gain insight into the relation between LA action and monoamine transporters, we investigated the effect of synthetic LAs on neurotransmitter transporters, including monoamine transporters. We used cloned transporter cDNAs and examined transient functional expression in COS cells and stable expression in HeLa cells… 
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