Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.

@article{Devy2009SelectiveIO,
  title={Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.},
  author={L. Devy and Li-li Huang and L. Naa and N. Yanamandra and H. Pieters and Nicolas Frans and Edward F. Chang and Qingfeng Tao and M. Vanhove and A. Lejeune and R. van Gool and D. Sexton and Guannan Kuang and D. Rank and S. Hogan and C. Pazmany and Yu Ma and S. Schoonbroodt and A. Nixon and R. Ladner and R. Hoet and P. Henderikx and C. Tenhoor and S. Rabbani and M. Valentino and C. Wood and D. Dransfield},
  journal={Cancer research},
  year={2009},
  volume={69 4},
  pages={
          1517-26
        }
}
Inhibition of specific matrix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role in tumor growth, invasion, and neovascularization. Besides cleaving matrix proteins, MMP-14 activates proMMP-2 leading to an amplification of pericellular proteolytic activity. To examine the contribution of MMP-14 to tumor growth and angiogenesis, we used DX-2400, a highly selective fully human MMP… Expand
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