Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.

@article{Pelletier1999SelectiveIO,
  title={Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.},
  author={J. J. Pelletier and Viorica Lascau-Coman and Dragan V. Jovanovic and Julio Cesar Lombaldo Fernandes and Pamela T. Manning and James R. Connor and Mark G. Currie and Johanne Martel-Pelletier},
  journal={The Journal of rheumatology},
  year={1999},
  volume={26 9},
  pages={2002-14}
}
OBJECTIVE We used the experimental dog model of osteoarthritis (OA) to examine the in vivo effects of N-iminoethyl-L-lysine (L-NIL), a selective inhibitor of the inducible nitric oxide synthase (iNOS), on the tissue level and distribution of interleukin-1beta (IL-1beta), collagenase-1, stromelysin-1, cyclooxygenase-2 (COX-2), iNOS and nitrotyrosine, through immunohistochemical and morphometric analysis. METHODS Cartilage and synovial membrane specimens were obtained from 3 experimental groups… CONTINUE READING