Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase.

@article{Naccache1990SelectiveIO,
  title={Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase.},
  author={Paul H. Naccache and Chris Gilbert and Adriana C Caon and Muriel Gaudry and Christopher K Huang and V A Bonak and Kazuo Umezawa and Shaun R McColl},
  journal={Blood},
  year={1990},
  volume={76 10},
  pages={2098-104}
}
The role of tyrosine kinases in the responses of human neutrophils to chemotactic factors was examined using the recently described inhibitor erbstatin. Pre-incubation with erbstatin decreased the amount of tyrosine phosphorylation induced by the formylated oligopeptide formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe) without effecting the binding of [3H]-fMet-Leu-Phe. Erbstatin also dose-dependently inhibited the production of superoxide anion induced by fMet-Leu-Phe and platelet… CONTINUE READING

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