Selective inhibition of human group IIA-secreted phospholipase A2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes.

Abstract

Human group IIA secreted phospholipase A2 (hGIIA) promotes tumor growth and inflammation and can act independently of its well described catalytic lipase activity via an alternative poorly understood signaling pathway. With six chemically diverse inhibitors we show that it is possible to selectively inhibit hGIIA signaling over catalysis, and x-ray crystal… (More)
DOI: 10.1074/jbc.M112.397893

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@article{Lee2013SelectiveIO, title={Selective inhibition of human group IIA-secreted phospholipase A2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes.}, author={Lawrence K. Lee and Katherine J. Bryant and Romaric Bouveret and P. W. Lei and Anthony P. Duff and Stephen J. Harrop and Edwin P. Huang and Richard P. Harvey and Michael H. Gelb and Peter P. Gray and Paul M. G. Curmi and Anne Marie Cunningham and William Bret Church and Kieran F. Scott}, journal={The Journal of biological chemistry}, year={2013}, volume={288 21}, pages={15269-79} }