Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4- dicarboxylate.

@article{Schoepp1995SelectiveIO,
  title={Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4- dicarboxylate.},
  author={Darryle D. Schoepp and Bryan G. Johnson and Craig R. Salhoff and Matthew J Valli and Mohamed A. Desai and J. P. Burnett and Nancy G. Mayne and James A. Monn},
  journal={Neuropharmacology},
  year={1995},
  volume={34 8},
  pages={843-50}
}
Metabotropic glutamate receptors (mGluRs) are a heterogeneous family of G-protein coupled receptors that are linked to multiple second messengers in the rat hippocampus. The compound 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) has been widely used to activate this class of receptors and study their functions in situ. However, 1S,3R-ACPD acts on multiple mGluR subtypes to produce multiple alterations in second messengers. We report here that the aza-substituted analog of 1S,3R… CONTINUE READING

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