Selective inhibition of cyclooxygenase 2-generated prostaglandin E2 synthesis in rheumatoid arthritis synoviocytes by taurine chloramine.

@article{Kontny2003SelectiveIO,
  title={Selective inhibition of cyclooxygenase 2-generated prostaglandin E2 synthesis in rheumatoid arthritis synoviocytes by taurine chloramine.},
  author={Ewa Kontny and Weronika Rudnicka and Jacek Kowalczewski and Janusz Marcinkiewicz and Wlodzimierz Maśliński},
  journal={Arthritis and rheumatism},
  year={2003},
  volume={48 6},
  pages={1551-5}
}
OBJECTIVE To investigate the effects of taurine chloramine (Tau-Cl), a chlorinated derivative of the amino acid taurine, on the expression of cyclooxygenase (COX) isoenzymes and prostaglandin E(2) (PGE(2)) synthesis in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS). METHODS FLS, isolated from the synovial tissue of RA patients, were treated in vitro with either interleukin-1beta (IL-1beta; 1 ng/ml) alone or together with 200-500 microM Tau-Cl. The expression of COX isoenzymes… CONTINUE READING

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