Selective inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensis.

@article{Reddy2000SelectiveIO,
  title={Selective inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensis.},
  author={Christopher M Reddy and V B Bhat and Gaddam Kiranmai and M. Narsi Reddy and Pallu Reddanna and Kattigere M. Madyastha},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={277 3},
  pages={
          599-603
        }
}
We report data from two related assay systems (isolated enzyme assays and whole blood assays) that C-phycocyanin a biliprotein from Spirulina platensis is a selective inhibitor of cyclooxygenase-2 (COX-2) with a very low IC(50) COX-2/IC(50) COX-1 ratio (0.04). The extent of inhibition depends on the period of preincubation of phycocyanin with COX-2, but without any effect on the period of preincubation with COX-1. The IC(50) value obtained for the inhibition of COX-2 by phycocyanin is much… 
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