Selective inhibition of amino-terminal methionine processing by TNP-470 and ovalicin in endothelial cells.

@article{Turk1999SelectiveIO,
  title={Selective inhibition of amino-terminal methionine processing by TNP-470 and ovalicin in endothelial cells.},
  author={Benjamin E. Turk and Eric C. Griffith and Sandra J. Wolf and Klaus Biemann and Yoong Hee Chang and Jun O Liu},
  journal={Chemistry & biology},
  year={1999},
  volume={6 11},
  pages={823-33}
}
BACKGROUND The angiogenesis inhibitors TNP-470 and ovalicin potently suppress endothelial cell growth. Both drugs also specifically inhibit methionine aminopeptidase 2 (MetAP2) in vitro. Inhibition of MetAP2 and changes in initiator methionine removal in drug-treated endothelial cells have not been demonstrated, however. RESULTS Concentrations of TNP-470 sufficient to inactivate MetAP2 in intact endothelial cells were comparable to those that inhibited cell proliferation, suggesting that… CONTINUE READING