Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop.

Abstract

Regulators of G-protein signaling (RGS) proteins act directly on Galpha subunits to increase the rate of GTP hydrolysis and to terminate signaling. However, the mechanisms involved in determining their specificities of action in cells remain unclear. Recent evidence has raised the possibility that RGS proteins may interact directly with G-protein-coupled… (More)

Topics

Cite this paper

@article{Hague2005SelectiveIO, title={Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop.}, author={Chris Hague and Leah S Bernstein and Suneela Ramineni and Zhongjian Chen and Kenneth P. Minneman and John R. Hepler}, journal={The Journal of biological chemistry}, year={2005}, volume={280 29}, pages={27289-95} }