Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.

@article{Ghosh2007SelectiveIO,
  title={Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.},
  author={Anamitra Ghosh and Avik Roy and Xiaojuan Liu and Jeffrey H. Kordower and Elliott J. Mufson and Dean M. Hartley and Sankar Ghosh and R. Lee Mosley and Howard E. Gendelman and Kalipada Pahan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 47},
  pages={18754-9}
}
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Despite intense investigations, no effective therapy is available to stop its onset or halt its progression. The present study evaluates the ability of peptide corresponding to the NF-kappaB essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and establish a role for NF… CONTINUE READING
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