Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model.

@article{Gao2009SelectiveIO,
  title={Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model.},
  author={Yong-Jing Gao and Jen-Kun Cheng and Qing T Zeng and Zhao Xu and Isabelle Decosterd and Xiaoyin Xu and Rongrong Ji},
  journal={Experimental neurology},
  year={2009},
  volume={219 1},
  pages={146-55}
}
Cancer pain significantly affects the quality of cancer patients, and current treatments for this pain are limited. C-Jun N-terminal kinase (JNK) has been implicated in tumor growth and neuropathic pain sensitization. We investigated the role of JNK in cancer pain and tumor growth in a skin cancer pain model. Injection of luciferase-transfected B16-Fluc melanoma cells into a hindpaw of mouse induced robust tumor growth, as indicated by increase in paw volume and fluorescence intensity. Pain… CONTINUE READING

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