Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors.

@article{Geron2008SelectiveIO,
  title={Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors.},
  author={Ifat Geron and Annelie E Abrahamsson and Charlene F Barroga and Edward Kavalerchik and Jason Gotlib and John D. Hood and Jeffrey A Durocher and Chi Ching Mak and Glenn Noronha and Richard M Soll and Ayalew Tefferi and Ken Kaushansky and Catriona H. M. Jamieson},
  journal={Cancer cell},
  year={2008},
  volume={13 4},
  pages={321-30}
}
Polycythemia Vera (PV) is a myeloproliferative disorder (MPD) that is commonly characterized by mutant JAK2 (JAK2V617F) signaling, erythrocyte overproduction, and a propensity for thrombosis, progression to myelofibrosis, or acute leukemia. In this study, JAK2V617F expression by human hematopoietic progenitors promoted erythroid colony formation and erythroid engraftment in a bioluminescent xenogeneic immunocompromised mouse transplantation model. A selective JAK2 inhibitor, TG101348 (300 nM… CONTINUE READING