Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid‐like fatty acid amides

@article{Fichna2014SelectiveIO,
  title={Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid‐like fatty acid amides},
  author={J. Fichna and M. Sałaga and J. Stuart and D. Saur and M. Sobczak and H. Zatorski and J. Timmermans and H. Bradshaw and K. Ahn and M. Storr},
  journal={Neurogastroenterology & Motility},
  year={2014},
  volume={26}
}
The endogenous cannabinoid system (ECS) plays a crucial role in multiple physiological processes in the central nervous system and in the periphery. The discovery that selective cannabinoid (CB) receptor agonists exert a potent inhibitory action on gastrointestinal (GI) motility and pain has placed the ECS in the center of attention as a possible target for the treatment of functional GI diseases. However, side effects of CB agonists prompted the search for novel therapeutic targets. Here, the… Expand
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