Corpus ID: 45788910

Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis.

  title={Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis.},
  author={M. Hansen-Petrik and M. Mcentee and Benjamin T. Johnson and M. Obukowicz and J. Masferrer and B. Zweifel and C. Chiu and J. Whelan},
  journal={Cancer letters},
  volume={175 2},
Arachidonic acid is an important polyunsaturated fatty acid involved in cell signaling. It is derived primarily from dietary linoleic acid, and the rate-limiting step in its biosynthesis is the initial desaturation of linoleic acid via Delta-6 desaturase. Evidence suggests that downstream metabolic products of arachidonic acid, e.g. prostaglandins, are involved in colorectal cancer, but involvement of the biosynthetic pathway of arachidonic acid has not been previously investigated. In the… Expand
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