Selective inhibition of Alu retrotransposition by APOBEC3G.

  title={Selective inhibition of Alu retrotransposition by APOBEC3G.},
  author={Amy E. Hulme and Hal P. Bogerd and Bryan R Cullen and John V Moran},
  volume={390 1-2},
The non-LTR retrotransposon LINE-1 (L1) comprises approximately 17% of the human genome, and the L1-encoded proteins can function in trans to mediate the retrotransposition of non-autonomous retrotransposons (i.e., Alu and probably SVA elements) and cellular mRNAs to generate processed pseudogenes. Here, we have examined the effect of APOBEC3G and APOBEC3F, cytidine deaminases that inhibit Vif-deficient HIV-1 replication, on Alu retrotransposition and other L1-mediated retrotransposition… CONTINUE READING
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