Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
@article{Makara2005SelectiveIO, title={Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus}, author={Judit K. Makara and Marco Mor and Darren Fegley and Szil{\'a}rd I. Szab{\'o} and Satish Kathuria and Giuseppe Astarita and Andrea Duranti and Andrea Tontini and Giorgio Tarzia and Silvia Rivara and Tam{\'a}s F. Freund and Daniele Piomelli}, journal={Nature Neuroscience}, year={2005}, volume={8}, pages={1139-1141} }
The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that two previously unknown inhibitors of monoacylglycerol lipase, a presynaptic enzyme that hydrolyzes 2-AG, increase 2-AG levels and enhance retrograde signaling from pyramidal neurons to GABAergic terminals in the hippocampus. These results establish a role for 2-AG in synaptic plasticity and point to monoacylglycerol lipase as a possible drug target.
161 Citations
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