Selective inhibition by zatebradine and discrete parasympathetic stimulation of the positive chronotropic response to sympathetic stimulation in anesthetized dogs.

@article{Furukawa1995SelectiveIB,
  title={Selective inhibition by zatebradine and discrete parasympathetic stimulation of the positive chronotropic response to sympathetic stimulation in anesthetized dogs.},
  author={Yasuyuki Furukawa and Hirofumi Nakano and Takeshi Oguchi and Miho Kasama and Yuji Hoyano and Shigetoshi Chiba},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={272 2},
  pages={744-9}
}
To investigate how to reduce the positive chronotropic response to sympathetic nerve activation selectively without affecting other cardiac actions, we studied the effects of zatebradine, an inhibitor of the hyperpolarization-activated current (I(f)), verapamil and parasympathetic nerve stimulation on the positive chronotropic, dromotropic and inotropic responses to sympathetic nerve stimulation in the autonomically decentralized heart of the open-chest anesthetized dog. Parasympathetic input… CONTINUE READING

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