Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells.

@article{Sarkar2005SelectiveIB,
  title={Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells.},
  author={Kakali Sarkar and Michael J. Kruhlak and Stanley L. Erlandsen and Stephen Shaw},
  journal={Immunology},
  year={2005},
  volume={116 4},
  pages={513-24}
}
We present here the analysis of fluid-phase endocytosis (FPE) in human blood monocytes and monocyte-derived dendritic cells (MDDC) facilitated by our serendipitous identification of rottlerin as an efficient inhibitor of dendritic cell FPE (IC(50) of 0.4 microM). Rottlerin was found to be an excellent tool for FPE analysis: rapid-acting, irreversible and selective for FPE (as opposed to receptor-mediated endocytosis) at concentrations of 3 microM and below. The inhibitory effect was not due to… CONTINUE READING
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