Selective inhibition by ethylisopropylamiloride of the positive inotropic effect evoked by low concentrations of ouabain in rat isolated ventricles.

Abstract

The biphasic positive inotropic effect of ouabain has been studied in rat ventricular strips in the presence of ethylisopropylamiloride (EIPA) an inhibitor of Na+/H+ exchange. EIPA (10-20 microM) depressed dose-dependently the high affinity component of the ouabain inotropic effect, whereas it did not significantly modify the low affinity inotropic effect… (More)

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@article{Finet1986SelectiveIB, title={Selective inhibition by ethylisopropylamiloride of the positive inotropic effect evoked by low concentrations of ouabain in rat isolated ventricles.}, author={Michel Finet and Th{\'e}ophile Godfraind}, journal={British journal of pharmacology}, year={1986}, volume={89 3}, pages={533-8} }