Selective induction of tissue inhibitor of metalloproteinase-1 in bleomycin-induced pulmonary fibrosis.

@article{Madtes2001SelectiveIO,
  title={Selective induction of tissue inhibitor of metalloproteinase-1 in bleomycin-induced pulmonary fibrosis.},
  author={David K. Madtes and Alejandra Elston and Lee A. Kaback and Joan G. Clark},
  journal={American journal of respiratory cell and molecular biology},
  year={2001},
  volume={24 5},
  pages={599-607}
}
Tissue inhibitors of metalloproteinases (TIMPs) are multifunctional proteins that have the capacity to modify cellular activities and to modulate matrix turnover. We demonstrate that TIMP-1 messenger RNA (mRNA) and protein expression are selectively and markedly increased in a murine model of bleomycin-induced pulmonary fibrosis. Northern analysis showed… CONTINUE READING