Selective induction of pancreatic ductular tumors by single doses of N-nitrosobis(2-oxopropyl)amine in Syrian golden hamsters.

Abstract

The selectivity of response by the Syrian hamster pancreas to the neoplastic effect of N-nitrosobis(2-oxopropyl)amine (BOP) was demonstrated by single subcutaneous injections of the compound. Only occasional tumors were induced simultaneously with those of the pancreas in the biliary ducts, kidneys and lungs of a few hamsters. In the pancreas, the ductules, especially those of an intrainsular location, were the cells primarily affected. The responded to doses as low as 1/40 of the LD50, whereas ductal lesions were found only in some hamsters treated with doses above 1/5 of the LD50. Hence it is concluded that hamster ductular cells are the most responsive to the carcinogenic action of BOP.

0200400'80'83'87'91'95'99'03'07'11'15
Citations per Year

848 Citations

Semantic Scholar estimates that this publication has 848 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Pour1978SelectiveIO, title={Selective induction of pancreatic ductular tumors by single doses of N-nitrosobis(2-oxopropyl)amine in Syrian golden hamsters.}, author={Parviz M. Pour and Said Zehtab Salmasi and Roswitha Runge}, journal={Cancer letters}, year={1978}, volume={4 6}, pages={317-23} }