Selective induction of gene expression and second-messenger accumulation in Dictyostelium discoideum by the partial chemotactic antagonist 8-p- chlorophenylthioadenosine 3',5'-cyclic monophosphate Peters,


During development of the cellular slime mold Dictyostelium discoideum, cAMP induces chemotaxis and expression of different classes of genes by means of interaction with surface cAMP receptors. We describe a cAMP derivative, 8-p-chlqrophenylthioadenosine 3',5'-cyclic monophosphate (8CPT-cAMP), which inhibits cAMP-induced chemotaxis at low concentrations but… (More)


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