Corpus ID: 12623444

Selective induction of G2/M arrest and apoptosis in HL-60 by a potent anticancer agent, HMJ-38.

@article{Yang2004SelectiveIO,
  title={Selective induction of G2/M arrest and apoptosis in HL-60 by a potent anticancer agent, HMJ-38.},
  author={J. Yang and Mann-Jen Hour and S. Kuo and L. Huang and Miau-Rong Lee},
  journal={Anticancer research},
  year={2004},
  volume={24 3a},
  pages={
          1769-78
        }
}
We previously reported that HMJ-38 was the most potent 2-phenyl-4-quinozolinone derivative in inhibiting tubulin polymerization and showed significant cytotoxicity against several human tumor cell lines. In this work, we studied its cytotoxic effect on HL-60 leukemia cells and the underlying mechanisms. We first investigated the effects of HMJ-38 on viability, cell cycle and induction of apoptosis in HL-60 and normal human peripheral blood mononuclear cells (PBMC). After 24-hour treatment with… Expand
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