Selective induction of CTL helper rather than killer activity by natural epitope variants promotes dendritic cell-mediated HIV-1 dissemination.

@article{Mailliard2013SelectiveIO,
  title={Selective induction of CTL helper rather than killer activity by natural epitope variants promotes dendritic cell-mediated HIV-1 dissemination.},
  author={Robbie B. Mailliard and Kellie N Smith and Ronald J. Fecek and Giovanna Rappocciolo and Eduardo J. M. Nascimento and Ernesto Torres De Azeved Marques and Simon C. Watkins and James I. Mullins and Charles R. Rinaldo},
  journal={Journal of immunology},
  year={2013},
  volume={191 5},
  pages={2570-80}
}
The ability of HIV-1 to rapidly accumulate mutations provides the virus with an effective means of escaping CD8(+) CTL responses. In this study, we describe how subtle alterations in CTL epitopes expressed by naturally occurring HIV-1 variants can result in an incomplete escape from CTL recognition, providing the virus with a selective advantage. Rather than paralyzing the CTL response, these epitope modifications selectively induce the CTL to produce proinflammatory cytokines in the absence of… CONTINUE READING
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