Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis.

@article{Schutyser2001SelectiveIO,
  title={Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis.},
  author={Evemie Schutyser and Sofie Struyf and Anja Wuyts and Willy Put and Karel Geboes and Bernard Grillet and Ghislain Opdenakker and Jo Van Damme},
  journal={European journal of immunology},
  year={2001},
  volume={31 12},
  pages={3755-62}
}
Chemokines are mediators of innate and acquired immunity. CCL18, also designated pulmonary and activation-regulated chemokine (PARC), dendritic cell-derived CC chemokine-1 (DC-CK1), alternative macrophage activation-associated CC chemokine-1 (AMAC-1) and macrophage inflammatory protein-4 (MIP-4), was for the first time isolated from peripheral blood mononuclear cells (PBMC) and biochemically characterized. We found that CCL18/PARC protein is spontaneously secreted by PBMC and is selectively… CONTINUE READING