Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli.

@article{Faulkner1998SelectiveIO,
  title={Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli.},
  author={Kim K. Faulkner and Richard Mithen and Gary Williamson},
  journal={Carcinogenesis},
  year={1998},
  volume={19 4},
  pages={605-9}
}
The putative anticarcinogenic activity of Brassica vegetables has been associated with the presence of certain glucosinolates. 4-Methylsulphinylbutyl isothiocyanate (sulphoraphane), derived from the corresponding glucosinolate found in broccoli, has previously been identified as a potent inducer of the anticarcinogenic marker enzyme quinone reductase [NADP(H):quinone-acceptor oxidoreductase] in murine hepatoma Hepa 1c1c7 cells. We have therefore produced a broccoli hybrid with increased levels… CONTINUE READING

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References

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Showing 1-10 of 17 references

Direct measurement of NAD ( P ) H : quinone reductase from cells cultured in microtitre wells : A screening assay for anticarcinogenic enzyme inducers

  • G. Williamson, G. W. Plumb, Y. Uda, K. R. Price, M. J. C. Rhodes
  • Anal . Biochem .
  • 1996

Glucosinolates of wild and cultivated Brassica species

  • A. Giamoustaris, R. Mithen
  • Phytochemistry
  • 1996

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

  • E. J. R. Bouhuon, D. J. Keith, I. A. P. Parkin, A. G. Sharpe, D. J. Lydiate
  • Proc . Natl Acad . Sci . USA
  • 1996

: glucosinolate breakdown products assessed by induction of quinone reductase activity in murine Hepa 1 c 1 c 7 cells

  • Y. Zhang, T. W. Kensler, C.-G. Cho, G. H. Posner, P. Talalay
  • 1994

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