Selective incorporation of docosahexaenoic acid into lysobisphosphatidic acid in cultured THP-1 macrophages

@article{Besson2006SelectiveIO,
  title={Selective incorporation of docosahexaenoic acid into lysobisphosphatidic acid in cultured THP-1 macrophages},
  author={Nelly Besson and Françoise Hullin-Matsuda and Asami Makino and Motohide Murate and Michel Lagarde and J P Pageaux and Toshihide Kobayashi and Isabelle Delton-Vandenbroucke},
  journal={Lipids},
  year={2006},
  volume={41},
  pages={189-196}
}
Lysobisphosphatidic acid (LBPA) is highly accumulated in specific domains of the late endosome and is involve in the biogenesis and function of this organelle. Little is known about the biosynthesis and metabolism of this lipid. We examined its FA composition and the incorporation of exogenous FA into LBPA in the human monocytic leukemia cell line THP-1. The LBPA FA composition in THP-1 cells exhibits an elevated amount of oleic acid (18∶1n−9) and enerichment of PUFA, especially DHA (22∶6n−3… CONTINUE READING
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