Selective inactivation of two components of the multiprotein transcription factor TFIIIB in cycloheximide growth-arrested yeast cells.

@article{Dieci1995SelectiveIO,
  title={Selective inactivation of two components of the multiprotein transcription factor TFIIIB in cycloheximide growth-arrested yeast cells.},
  author={Giorgio Dieci and L Duimio and Giovanna Peracchia and Simone Ottonello},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 22},
  pages={13476-82}
}
Following protein synthesis inhibition in cycloheximide growth-arrested yeast cells, the rates of tRNA and 5 S RNA synthesis decrease with apparent half-times of about 20 and 10 min, respectively. This effect is mimicked by extracts of treated cells, and the impairment of tRNA gene transcription activity that is observed in vitro parallels the in vivo inactivation of RNA polymerase III transcription. As revealed by experiments in which partially purified class III transcription factors were… CONTINUE READING

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