Corpus ID: 11930140

Selective inactivation of rat liver cytochromes P-450 by 21-chlorinated steroids.

@article{Halpert1989SelectiveIO,
  title={Selective inactivation of rat liver cytochromes P-450 by 21-chlorinated steroids.},
  author={James R. Halpert and John Yan Jaw and Linda J. Cornfield and Celia A. Balfour and Eugene A. Mash},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1989},
  volume={17 1},
  pages={
          26-31
        }
}
  • J. Halpert, J. Jaw, +2 authors E. Mash
  • Published 1989
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
The inactivation by 21-chlorinated steroids of rat liver cytochromes P-450 involved in the hydroxylation of progesterone and androstenedione has been investigated. Preincubation of intact liver microsomes from phenobarbital-treated rats with 21-chloropregnenolone, 21,21-dichloropregnenolone, or 21,21-dichloroprogesterone in the presence of NADPH caused a time-dependent decrease in progesterone 21-hydroxylase and in progesterone or androstenedione 6 beta-hydroxylase activity but had negligible… Expand
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