Selective inactivation of NADPH oxidase 2 causes regression of vascularization and the size and stability of atherosclerotic plaques.

@article{Quesada2015SelectiveIO,
  title={Selective inactivation of NADPH oxidase 2 causes regression of vascularization and the size and stability of atherosclerotic plaques.},
  author={Isabel Quesada and Adam Lucero and Clarissa Amaya and Daniel N. Meijles and M Eugenia Cifuentes and Patrick J Pagano and Claudia Castro},
  journal={Atherosclerosis},
  year={2015},
  volume={242 2},
  pages={469-75}
}
BACKGROUND A variety of NADPH oxidase (Nox) isoforms including Noxs 1, 2, 4 and 5 catalyze the formation of reactive oxygen species (ROS) in the vascular wall. The Nox2 isoform complex has arguably received the greatest attention in the progression of atherogenesis in animal models. Thus, in the current study we postulated that specific Nox2 oxidase inhibition could reverse or attenuate atherosclerosis in mice fed a high-fat diet. METHODS We evaluated the effect of isoform-selective Nox2… CONTINUE READING
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