Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models.

@article{Bertrand1990SelectiveIO,
  title={Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models.},
  author={Claude Bertrand and Eric Tschirhart and Yves Landry},
  journal={Agents and actions. Supplements},
  year={1990},
  volume={31},
  pages={247-50}
}
In an IgE and an IgG model of anaphylaxis in the guinea pig, we investigated the role of prostanoids and PAF-acether in the tracheal response in vitro to immunochallenge. Indomethacin (10(-6) M) potentiated the antigen-induced contraction in both models suggesting the synthesis of relaxant prostaglandins during the anaphylactic phenomenon. UK-38,485 (10(-5… CONTINUE READING