Selective impairment of respiration in mitochondria isolated from brain subregions following transient forebrain ischemia in the rat.

@article{Sims1991SelectiveIO,
  title={Selective impairment of respiration in mitochondria isolated from brain subregions following transient forebrain ischemia in the rat.},
  author={Neil Sims},
  journal={Journal of neurochemistry},
  year={1991},
  volume={56 6},
  pages={1836-44}
}
  • Neil Sims
  • Published 1991 in Journal of neurochemistry
Using Percoll density gradient centrifugation, free (nonsynaptosomal) mitochondria were isolated from the dorsal-lateral striatum and paramedian neocortex of rats during complete forebrain ischemia and reperfusion. Mitochondria prepared from either region after 30 min of ischemia showed decreased state 3 (ADP and substrate present) and uncoupled respiration rates (19-45% reductions) with pyruvate plus malate as substrates, whereas state 4 respiration (no ADP present) was preserved. At 6 h of… CONTINUE READING
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