Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

@article{Morris1986SelectiveIO,
  title={Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5},
  author={R G Morris and E. Anderson and Gary Lynch and Michel Baudry},
  journal={Nature},
  year={1986},
  volume={319},
  pages={774-776}
}
Recent work has shown that the hippocampus contains a class of receptors for the excitatory amino acid glutamate that are activated by N-methyl-D-aspartate (NMDA)1 and that exhibit a peculiar dependency on membrane voltage in becoming active only on depolarization2,3. Blockade of these sites with the drug aminophosphonovaleric acid (AP5) does not detectably affect synaptic transmission in the hippocampus, but prevents the induction of hippocampal long-term potentiation (LTP) following brief… Expand

Paper Mentions

Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5
  • R. Morris
  • Psychology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1989
TLDR
The results show that chronic intraventricular infusion of the NMDA receptor antagonist D,L-2-amino-5-phosphonopentanoic acid (D,L, AP5) caused an impairment of spatial but not of visual discrimination learning in rats. Expand
Distinct components of spatial learning revealed by prior training and NMDA receptor blockade
TLDR
It is reported that the AP5-induced learning deficit can be almost completely prevented if rats are pretrained in a different watermaze before administration of the drug. Expand
Spatial learning without NMDA receptor-dependent long-term potentiation
TLDR
It is reported that NPC17742 completely blocked dentate gyrus LTP but did not prevent normal spatial learning in rats that had been made familiar with the general task requirements by non-spatial pretraining, indicating that this form of LTP is not required for normal spatiallearning in the watermaze. Expand
Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine
TLDR
It is reported here that intraventricular infusions of B6B21 significantly enhances acquisition rates in hippocampus-dependent trace eye blink conditioning in rabbits, halving the number of trials required to reach a criterion of 80% conditioned responses. Expand
A dose-related impairment of spatial learning by the NMDA receptor antagonist, 2-amino-5-phosphonovalerate (AP5)
TLDR
The results demonstrate that a selective N-methyl-D-aspartate receptor antagonist, D-2-amino-5-phosphonovalerate, causes a dose-related and correlated impairment of both spatial learning and hippocampal long term potentiation in vivo. Expand
Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP
In general, N-methyl-D-aspartate (NMDA) receptor antagonists inhibit learning and long term potentiation (LTP). However, it has been suggested that direct tonic, i.e. non-temporal, activation of NMDAExpand
Hippocampal NMDA receptors and the previous experience effect on memory
TLDR
It is hypothesize that changes in NMDAR composition could be involved in the "anti-amnesic effect" of the previous OF, and along certain time interval, an increase in GluN1 and GLUN2A would lead to a increase in synaptic N MDARs, facilitating synaptic plasticity and memory; while then, an increased in Glamorgan NMDar ratio could protect the synapse and the already established plasticity, perhaps saving the specific trace. Expand
Blockade of NMDA receptors pre-training, but not post-training, impairs object displacement learning in the rat
TLDR
The data show that rats injected intraperitoneally with CPP before, but not after, training in the object displacement task displayed impairments in spatial learning when compared with saline-injected controls, and provides evidence for a role for ERK in spatiallearning in the dentate gyrus of the rat. Expand
Differential effects of ibotenic acid lesions of the hippocampus and blockade of N-methyl-{d}-aspartate receptor-dependent long-term potentiation on contextual processing in rats.
The contextual specificity of appetitive conditioned responding was examined in rats undergoing chronic intracerebroventricular infusion of 15 or 30 mM D-2-amino-5-phosphonopentanoic acid (D-AP5) orExpand
Antagonists of the metabotropic glutamate receptor do not prevent induction of long-term potentiation in the dentate gyrus of rats.
TLDR
Results suggest that the mGlu receptor subtype blocked by MCPG and 4CPG is not involved in long-term potentiation in the dentate gyrus, and that the NMDA receptor antagonist, dl(-)-2-amino-5-phosphonopentanoic (dl-AP5), effectively blocked long- term potentiation. Expand
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