Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

@article{Morris1986SelectiveIO,
  title={Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5},
  author={R. Morris and E. Anderson and G. Lynch and M. Baudry},
  journal={Nature},
  year={1986},
  volume={319},
  pages={774-776}
}
  • R. Morris, E. Anderson, +1 author M. Baudry
  • Published 1986
  • Chemistry, Materials Science, Medicine
  • Nature
  • Recent work has shown that the hippocampus contains a class of receptors for the excitatory amino acid glutamate that are activated by N-methyl-D-aspartate (NMDA)1 and that exhibit a peculiar dependency on membrane voltage in becoming active only on depolarization2,3. Blockade of these sites with the drug aminophosphonovaleric acid (AP5) does not detectably affect synaptic transmission in the hippocampus, but prevents the induction of hippocampal long-term potentiation (LTP) following brief… CONTINUE READING

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