• DOI:10.1038/319774A0
Corpus ID: 4356601

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

@article{Morris1986SelectiveIO,
  title={Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5},
  author={R. Morris and E. Anderson and G. Lynch and M. Baudry},
  journal={Nature},
  year={1986},
  volume={319},
  pages={774-776}
}

R. Morris, E. Anderson, +1 author M. Baudry

Published 1986

Chemistry, Materials Science, Medicine

Nature

Recent work has shown that the hippocampus contains a class of receptors for the excitatory amino acid glutamate that are activated by N-methyl-D-aspartate (NMDA)1 and that exhibit a peculiar dependency on membrane voltage in becoming active only on depolarization2,3. Blockade of these sites with the drug aminophosphonovaleric acid (AP5) does not detectably affect synaptic transmission in the hippocampus, but prevents the induction of hippocampal long-term potentiation (LTP) following brief… CONTINUE READING

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