Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

@article{Morris1986SelectiveIO,
  title={Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5},
  author={R G Morris and E. Anderson and Gary Lynch and Michel Baudry},
  journal={Nature},
  year={1986},
  volume={319},
  pages={774-776}
}
Recent work has shown that the hippocampus contains a class of receptors for the excitatory amino acid glutamate that are activated by N-methyl-D-aspartate (NMDA)1 and that exhibit a peculiar dependency on membrane voltage in becoming active only on depolarization2,3. Blockade of these sites with the drug aminophosphonovaleric acid (AP5) does not detectably affect synaptic transmission in the hippocampus, but prevents the induction of hippocampal long-term potentiation (LTP) following brief… Expand
View on Springer
ncbi.nlm.nih.gov
3,421 Citations
Highly Influential Citations
88
Background Citations
811
Methods Citations
109
Results Citations
47

Paper Mentions

News Article
Flashes of light show how memories are made
Nature
2 June 2014

3,421 Citations

Citation Type

Citation Type

Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5
  • R. Morris
  • Psychology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1989
TLDR
The results show that chronic intraventricular infusion of the NMDA receptor antagonist D,L-2-amino-5-phosphonopentanoic acid (D,L, AP5) caused an impairment of spatial but not of visual discrimination learning in rats. Expand
Distinct components of spatial learning revealed by prior training and NMDA receptor blockade
TLDR
It is reported that the AP5-induced learning deficit can be almost completely prevented if rats are pretrained in a different watermaze before administration of the drug. Expand
Spatial learning without NMDA receptor-dependent long-term potentiation
TLDR
It is reported that NPC17742 completely blocked dentate gyrus LTP but did not prevent normal spatial learning in rats that had been made familiar with the general task requirements by non-spatial pretraining, indicating that this form of LTP is not required for normal spatiallearning in the watermaze. Expand
Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine
TLDR
It is reported here that intraventricular infusions of B6B21 significantly enhances acquisition rates in hippocampus-dependent trace eye blink conditioning in rabbits, halving the number of trials required to reach a criterion of 80% conditioned responses. Expand
A dose-related impairment of spatial learning by the NMDA receptor antagonist, 2-amino-5-phosphonovalerate (AP5)
TLDR
The results demonstrate that a selective N-methyl-D-aspartate receptor antagonist, D-2-amino-5-phosphonovalerate, causes a dose-related and correlated impairment of both spatial learning and hippocampal long term potentiation in vivo. Expand
Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP
In general, N-methyl-D-aspartate (NMDA) receptor antagonists inhibit learning and long term potentiation (LTP). However, it has been suggested that direct tonic, i.e. non-temporal, activation of NMDA… Expand
Hippocampal NMDA receptors and the previous experience effect on memory
TLDR
It is hypothesize that changes in NMDAR composition could be involved in the "anti-amnesic effect" of the previous OF, and along certain time interval, an increase in GluN1 and GLUN2A would lead to a increase in synaptic N MDARs, facilitating synaptic plasticity and memory; while then, an increased in Glamorgan NMDar ratio could protect the synapse and the already established plasticity, perhaps saving the specific trace. Expand
Blockade of NMDA receptors pre-training, but not post-training, impairs object displacement learning in the rat
TLDR
The data show that rats injected intraperitoneally with CPP before, but not after, training in the object displacement task displayed impairments in spatial learning when compared with saline-injected controls, and provides evidence for a role for ERK in spatiallearning in the dentate gyrus of the rat. Expand
Differential effects of ibotenic acid lesions of the hippocampus and blockade of N-methyl-{d}-aspartate receptor-dependent long-term potentiation on contextual processing in rats.
The contextual specificity of appetitive conditioned responding was examined in rats undergoing chronic intracerebroventricular infusion of 15 or 30 mM D-2-amino-5-phosphonopentanoic acid (D-AP5) or… Expand
Antagonists of the metabotropic glutamate receptor do not prevent induction of long-term potentiation in the dentate gyrus of rats.
TLDR
Results suggest that the mGlu receptor subtype blocked by MCPG and 4CPG is not involved in long-term potentiation in the dentate gyrus, and that the NMDA receptor antagonist, dl(-)-2-amino-5-phosphonopentanoic (dl-AP5), effectively blocked long- term potentiation. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors
TLDR
The results demonstrate that NMDA receptors present in hippocampal region CA1 are not necessary for normal synaptic transmission, but are involved in the initiation of long-term synaptic plasticity. Expand
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
TLDR
Using voltage-clamp experiments on mouse spinal cord neurones, it is shown that the voltage-sensitivity of NMDA action is greatly reduced on the withdrawal of physiological concentrations (∼1 mM) of Mg2+ from the extracellular fluid, providing further evidence that Mg 2+ blocks inward current flow through ion channels linked to NMDA receptors. Expand
Magnesium gates glutamate-activated channels in mouse central neurones
TLDR
The voltage dependence of the NMDA receptor-linked conductance appears to be a consequence of the voltage dependenceof the Mg2+ block and its interpretation does not require the implication of an intramembrane voltage-dependent ‘gate’. Expand
The antagonism of amino acid‐induced excitations of rat hippocampal CA1 neurones in vitro.
TLDR
DGG and APV did not affect ACh excitations and these selective antagonists should be of value in studying the involvement of the excitatory amino acids in synaptic transmission in the hippocampus, while PDA, GDEE, D‐ and L‐APB may be less useful in this regard. Expand
The effects of central catecholamine depletions on spatial learning in rats
TLDR
It is suggested that considerable spatial learning can occur in the absence of each of the major telencephalic catecholamine systems. Expand
Place navigation impaired in rats with hippocampal lesions
TLDR
It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure. Expand
A behavioural analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat
TLDR
Spatial localization by rats with different types of hippocampal damage was compared with vehicle-injected and normal control groups in the Morris water task, finding that all lesion groups, except the unilateral CA3-damaged group, were impaired at finding the platform. Expand
Anticonvulsant action of excitatory amino acid antagonists.
TLDR
Specific antagonists of excitation that is caused by amino acids provide a new class of anticonvulsant agents, and the most potent such compound was 2-amino-7-phosphonoheptanoic acid. Expand
Possible cellular basis for prolonged changes of synaptic efficiency--a simple case of learning.
  • P. Andersen
  • Psychology, Medicine
  • Progress in brain research
  • 1983
TLDR
This chapter focuses on possible cellular basis for prolonged changes of synaptic efficiency in nerve cells and their connections. Expand
A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats.
TLDR
The results suggest that the frontal andParietal cortex of rats play different roles in the control of spatial orientation but do not support the view that egocentric and allocentric spatial orientation are related to frontal and parietal mechanisms, respectively. Expand
...
1
2
...