Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

@article{Morris1986SelectiveIO,
  title={Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5},
  author={R. Morris and E. Anderson and G. Lynch and M. Baudry},
  journal={Nature},
  year={1986},
  volume={319},
  pages={774-776}
}
  • R. Morris, E. Anderson, +1 author M. Baudry
  • Published 1986
  • Chemistry, Materials Science, Medicine
  • Nature
  • Recent work has shown that the hippocampus contains a class of receptors for the excitatory amino acid glutamate that are activated by N-methyl-D-aspartate (NMDA)1 and that exhibit a peculiar dependency on membrane voltage in becoming active only on depolarization2,3. Blockade of these sites with the drug aminophosphonovaleric acid (AP5) does not detectably affect synaptic transmission in the hippocampus, but prevents the induction of hippocampal long-term potentiation (LTP) following brief… CONTINUE READING
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    References

    SHOWING 1-10 OF 17 REFERENCES
    The effects of central catecholamine depletions on spatial learning in rats
    • 107
    Possible cellular basis for prolonged changes of synaptic efficiency--a simple case of learning.
    • P. Andersen
    • Psychology, Medicine
    • Progress in brain research
    • 1983
    • 5