Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

@article{Morris1986SelectiveIO,
  title={Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5},
  author={R G Morris and E. Anderson and Gary Lynch and Michel Baudry},
  journal={Nature},
  year={1986},
  volume={319},
  pages={774-776}
}
Recent work has shown that the hippocampus contains a class of receptors for the excitatory amino acid glutamate that are activated by N-methyl-D-aspartate (NMDA)1 and that exhibit a peculiar dependency on membrane voltage in becoming active only on depolarization2,3. Blockade of these sites with the drug aminophosphonovaleric acid (AP5) does not detectably affect synaptic transmission in the hippocampus, but prevents the induction of hippocampal long-term potentiation (LTP) following brief… 

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Spatial learning without NMDA receptor-dependent long-term potentiation

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Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine

It is reported here that intraventricular infusions of B6B21 significantly enhances acquisition rates in hippocampus-dependent trace eye blink conditioning in rabbits, halving the number of trials required to reach a criterion of 80% conditioned responses.

Differential effects of ibotenic acid lesions of the hippocampus and blockade of N-methyl-{d}-aspartate receptor-dependent long-term potentiation on contextual processing in rats.

Results indicate that rats are capable of processing contextual information in the absence of N-methyl-D-aspartate (NMDA) receptor-dependent LTP and demonstrate an important dissociation between the effects of hippocampal lesions and the blockade of NMDA receptors in the hippocampus.

Pharmacological evidence for a role of long-term potentiation in memory.

  • I. Izquierdo
  • Biology, Psychology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1994
The data reviewed here lend strong support to the hypothesis that LTP in areas of the brain known to be responsible for the storage and retrieval of declarative memories underlies memory processes.
...

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