Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice.

@article{Yamasaki2008SelectiveIO,
  title={Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice.},
  author={Sho Yamasaki and Mitsuyo Takase-Utsugi and Eri Ishikawa and Machie Sakuma and Keigo Nishida and Takashi K. Saito and Osami Kanagawa},
  journal={International immunology},
  year={2008},
  volume={20 10},
  pages={1289-97}
}
Gads is a Grb2-like adaptor protein expressed in hematopoietic cells. We demonstrated that mast cells from Gads(-/-) mice have selective functional defects. Bone marrow-derived mast cells from Gads(-/-) mice failed to induce Ca(2+) mobilization, degranulation and cytokine production upon cross-linking of FcepsilonRI. In vivo passive cutaneous anaphylaxis was also greatly impaired in Gads(-/-) mice. In contrast, Gads was dispensable for Toll-like receptor-mediated cytokine production in mast… CONTINUE READING

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