Selective hydrolysis of ether-containing glycerophospholipids by phospholipase A2 in rabbit lung.


The role of phospholipase A2 (PLA2) in the simultaneous generation of lyso-platelet-activating factor and arachidonic acid was investigated by examining the calcium dependency and substrate specificity of PLA2 activities in rabbit lung microsomes. Alkylarachidonoylglycerophosphocholine (alkylarachidonoyl-GPC) was preferentially hydrolyzed as compared to… (More)