Selective hydrolysis of chondroitin sulfates by hyaluronidase.

@article{Knudson1984SelectiveHO,
  title={Selective hydrolysis of chondroitin sulfates by hyaluronidase.},
  author={Warren Knudson and Martin Gundlach and Thomas M. Schmid and Hans-Ulrich Conrad},
  journal={Biochemistry},
  year={1984},
  volume={23 2},
  pages={368-75}
}
Chondroitin 4-sulfate and chondroitin 6-sulfate were incubated with testicular hyaluronidase in the presence of excess beta-glucuronidase. The beta-glucuronidase caused rapid removal of the nonreducing terminal beta-D-glucuronosyl residues from the oligosaccharides formed by the action of the hyaluronidase, destroying the oligosaccharide acceptors required for the transglycosylation activity of hyaluronidase and releasing free D-glucuronic acid at a rate that was equal to the rate of the… CONTINUE READING
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