Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system.

@article{Witkin2004SelectiveHH,
  title={Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system.},
  author={Jeffrey M. Witkin and David L. G. Nelson},
  journal={Pharmacology & therapeutics},
  year={2004},
  volume={103 1},
  pages={1-20}
}
Evidence exists to implicate the monoamine histamine in the control of arousal and cognitive functions. Antagonists of H(3) receptors are postsynaptic and presynaptic modulators of neural transmission in a variety of neuronal circuits relevant to cognition. Accumulating neuroanatomical, neurochemical, pharmacological, and behavioral data support the idea that H(3) receptor antagonists may function to improve cognitive performances in disease states (e.g., Alzheimer's disease and mild cognitive… CONTINUE READING
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