Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824.

@article{Atadja2004SelectiveGI,
  title={Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824.},
  author={Peter W Atadja and Lin Gao and Paul Kwon and Nancy Trogani and Heather F Walker and Meier Hsu and Lakshmi Yeleswarapu and Nagarajan Chandramouli and Larry B Perez and Richard W Versace and Arthur H W Wu and Lidia C Sambucetti and Peter Lassota and Dalia Cohen and Kenneth W. Bair and Alexander D Wood and Stacy W Remiszewski},
  journal={Cancer research},
  year={2004},
  volume={64 2},
  pages={689-95}
}
We have synthesized a histone deacetylase inhibitor, NVP-LAQ824, a cinnamic hydroxamic acid, that inhibited in vitro enzymatic activities and transcriptionally activated the p21 promoter in reporter gene assays. NVP-LAQ824 selectively inhibited growth of cancer cell lines at submicromolar levels after 48-72 h of exposure, whereas higher concentrations and longer exposure times were required to retard the growth of normal dermal human fibroblasts. Flow cytometry studies revealed that both tumor… CONTINUE READING

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