Selective gene expression in brain microglia mediated via adeno-associated virus type 2 and type 5 vectors

Abstract

Microglia represent a crucial cell population in the central nervous system, participating in the regulation and surveillance of physiological processes as well as playing key roles in the etiologies of several major brain disorders. The ability to target gene transfer vehicles selectively to microglia would provide a powerful new approach to investigations… (More)
DOI: 10.1038/sj.gt.3301925

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