Selective forces shaping diversity in the class I region of the major histocompatibility complex in dairy cattle.

@article{Codner2012SelectiveFS,
  title={Selective forces shaping diversity in the class I region of the major histocompatibility complex in dairy cattle.},
  author={Gemma F. Codner and Michel J Stear and Russell Reeve and Lucy Matthews and Shirley Ellis},
  journal={Animal genetics},
  year={2012},
  volume={43 3},
  pages={239-49}
}
The major histocompatibility complex (MHC) is one of the most diverse regions of the mammalian genome. Diversity in MHC genes is integral to their function in the immune system, and while pathogens play a key role in shaping this diversity, the contribution of other selective forces remains unclear. The controlled breeding of cattle offers an excellent model for the identification and exploration of these forces. We characterized the MHC class I genes present in a sample of Canadian Holstein A… CONTINUE READING

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