Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex.

  title={Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex.},
  author={Yu-ichi Kamikubo and Grazia Loredana Mendolicchio and Antonella Zampolli and Patrizia Marchese and Andrea S. Rothmeier and Jennifer Nagrampa Orje and Andrew J. Gale and Sriram Krishnaswamy and Andr{\'a}s Gruber and Henrik {\O}stergaard and Lars Christian Petersen and Wolfram Ruf and Zaverio M. Ruggeri},
  volume={130 14},
Safe and effective antithrombotic therapy requires understanding of mechanisms that contribute to pathological thrombosis but have a lesser impact on hemostasis. We found that the extrinsic tissue factor (TF) coagulation initiation complex can selectively activate the antihemophilic cofactor, FVIII, triggering the hemostatic intrinsic coagulation pathway independently of thrombin feedback loops. In a mouse model with a relatively mild thrombogenic lesion, TF-dependent FVIII activation sets the… 

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