Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.

@article{Sahu2008SelectiveER,
  title={Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.},
  author={Nisebita Sahu and Ana Mar{\'i}a San Mart{\'i}n Venegas and Dragana Jankovic and Wayne Mitzner and Julio Gomez-Rodriguez and Jennifer L. Cannons and Connie L. Sommers and Paul Love and Alan Sher and Pamela L Schwartzberg and Avery August},
  journal={Journal of immunology},
  year={2008},
  volume={181 9},
  pages={6125-31}
}
Itk and Txk/Rlk are Tec family kinases expressed in T cells. Itk is expressed in both Th1 and Th2 cells. By contrast, Txk is preferentially expressed in Th1 cells. Although Itk is required for Th2 responses in vivo and Txk is suggested to regulate IFN-gamma expression and Th1 responses, it remains unclear whether these kinases have distinct roles in Th cell differentiation/function. We demonstrate here that Txk-null CD4(+) T cells are capable of producing both Th1 and Th2 cytokines similar to… CONTINUE READING

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